Research shows new papaverine derivatives exhibit unique physico-chemical properties, suggesting potential applications in pharmacology.
2,3,9,10-Tetramethoxy-12-oxo-12- H -indolo [2,1- a]isoquinolinium chloride 1 (compound X) and 13-(3,4dimethoxyphenyl)-2,3,8,9-tetramethoxy-6 a ,12 a -diazadibenzo [a, g] fluorenylium chloride 2 (compound NF) are new papaverine oxidation products. A solution of compound 1 bleaches on addition of sodium hydroxide solution. A new entity, 2-(2-carboxy-4,5-dimethoxyphenyl)-6,7-dimethoxyisoquinolinium inner salt 3 (compound WP), is formed. The physico-chemical properties of compounds 1–3, such as solubility in water and lipophilicity, have been measured. The IC50 for compounds 1 and 3 was also assessed.
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Czyrski et al. (2011) studied this question.
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