Precipitation Inhibition by Small-Molecule Analogues To Sustain Drug Supersaturation

H NMR revealed concentration-dependent aromatic shielding consistent with ciprofloxacin···analogue heteroassociation, with danofloxacin producing the most substantial and most symmetric perturbations. These data sets support a kinetic mechanism in which isostructural analogues disrupt ciprofloxacin self-association, delay the formation of prenucleation aggregates, and prolong supersaturation. The findings establish small-molecule structural mimicry as a viable pathway for stabilizing supersaturation and guiding mechanism-based coformulation design.