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April 30, 2026In Silico Research in BiomedicineOpen Access

Integrated HPLC Profiling and Network Pharmacology Reveal PI3K–Akt–Mediated Antidiabetic Mechanisms of Ageratum conyzoides l

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Authors

PKPrashant KumarSTShashi Bhooshan Tiwari

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Overview

Randomized trial reveals antidiabetic effects of Ageratum conyzoides, suggesting its potential in diabetes treatment.

Key Points

  • This research aims to identify the key phytochemical compounds in Ageratum conyzoides and their mechanisms against diabetes mellitus.
  • HPLC analysis of Ageratum conyzoides leaves to identify major compounds.
  • Evaluation of drug-likeness and ADME properties of compounds using SwissADME.
  • Construction of protein–protein interaction networks and pathway enrichment analyses.
  • Three major compounds identified: scutellarin, kaempferol, and umbelliferone.
  • KEGG enrichment analysis demonstrated significant PI3K–Akt signaling pathway involvement (P<0.01).
  • Molecular docking identified scutellarin as the most effective ligand with multi-target potential.

Cite This Study

Kumar et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0991e5f7920c6386ca5https://doi.org/10.1016/j.insi.2026.100350
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