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February 1, 2006Seminars in Thrombosis and Hemostasis

The FVIIa-TF interaction activates FX and FIX; FXa on the TF cell generates a small amount of thrombin that activates platelets and factors VIII, V, and XI, leading to amplified thrombin generation on the activated platelet surface.

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Population

Cell-based model using lipopolysaccharide-activated monocytes and platelets, with physiologic concentrations…

Design

Preclinical

Authors

HRHarold R. RobertsMHMaureane HoffmanDMDougald M. Monroe

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Overview

Should not change practice; extends cell-based coagulation model in animals pending human validation.

Structured PICO

P
Population
Cell-based model using lipopolysaccharide-activated monocytes (as a source of tissue factor) and platelets, with physiologic concentrations of plasma procoagulants, tissue factor pathway inhibitor, antithrombin, and C1-esterase inhibitor
I
Intervention
Initiation of coagulation by factor VIIa (FVIIa) and calcium
O
Outcome
Thrombin generation (measured by chromogenic assay) and platelet activation (measured by P-selectin expression)surrogate

This cell-based model elucidates the sequential roles of tissue factor-bearing cells and activated platelets in the initiation and amplification phases of thrombin generation.

Cite This Study

Roberts et al. (2006) studied this question.

synapsesocial.com/papers/69f2f0c2e4cdef8ca70fcafchttps://doi.org/10.1055/s-2006-939552
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