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April 30, 2026Organic Letters2 citations

Modular Synthesis of Chiral Tetrasubstituted Allylic Amines via Nickel-Catalyzed Enantioselective Difunctionalization of Alkynes with Imines and Arylboronic Acids

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XHXiruo HanXWXiaojuan WangSLShuojia Li

Key Points

  • The aim is to develop a method for synthesizing chiral tetrasubstituted allylic amines using nickel catalysis.
  • Utilized a nickel-catalyzed asymmetric three-component reaction
  • Involved alkynes, sulfonylimines, and arylboronic acids
  • Conducted under mild reaction conditions to ensure high regioselectivity and stereoselectivity.
  • Successfully synthesized a range of enantioenriched tetrasubstituted allylic amines
  • Achieved excellent regioselectivity and stereoselectivity
  • Demonstrated the method's efficiency under mild conditions.

Abstract

-sulfonylimines and arylboronic reagents. This asymmetric three-component transformation furnished a wide range of enantioenriched tetrasubstituted allylic amines with excellent regioselectivity and stereoselectivity under mild conditions.

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Cite This Study

Han et al. (2026) studied this question.

synapsesocial.com/papers/69f2f0e31e5f7920c6386e25https://doi.org/10.1021/acs.orglett.6c01015
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