Development and characterization of bicalutamide-poloxamer F68 solid dispersion systems

The objective of the present work was to improve the dissolution rate of a poorly water-soluble drug, bicalutamide, by a solid dispersion technique. The solid dispersion systems of bicalutamide were prepared with poloxamer F68 in 1 : 1, 1 : 3, and 1 : 5 ratios using the melting method. The interaction of drug with polymer was evaluated by TLC, FTIR, and powder XRD. The results of powder XRD showed a significant decrease in the crystallinity of drug in the binary systems of bicalutamide. All binary systems of bicalutamide showed faster dissolution than pure drug alone (p < 0.001). However, among all binary systems studied, 1 : 1 proportion of bicalutamide : poloxamer was found to be excellent for dissolution enhancement (DP30: 99.98% ± 3.9) of bicalutamide. The higher ratios of poloxamer F68 (1 : 3 and 1 : 5) had retarded the release of drug from their corresponding binary systems which might be due to its gelling property in higher concentration.