Novel chitosan hybrid fluorinated thiourea derivatives as dual anti-microbial and anti-biofilm agents: tailoring molecular interactions, in silico toxicity, and docking simulation

Moustafa S. Abusaif; Ahmed Ragab; Mohamed A. Salem; Nabila A. Maziad; Yousry A. Ammar

doi:10.1039/d6ma00145a

January 1, 2026Materials AdvancesOpen Access

Novel chitosan hybrid fluorinated thiourea derivatives as dual anti-microbial and anti-biofilm agents: tailoring molecular interactions, in silico toxicity, and docking simulation

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Key Points

This research aims to develop and characterize new chitosan derivatives with anti-microbial and anti-biofilm properties.
Synthesis of chitosan isothiocyanate and hybridization with fluorinated amines to produce derivatives CHTUD1-3.
Molecular interactions and in silico toxicity assessments conducted through docking simulations.
Three novel chitosan fluorinated-thiourea derivatives (CHTUD1-3) were successfully synthesized.
Laboratory tests suggest improved anti-microbial and anti-biofilm properties compared to existing agents.
Initial toxicity results indicate safety profiles suitable for further investigation.

Implication

Novel compounds target bacteria and biofilms, indicating potential for improved treatment options.

Abstract

This article presents the synthesis of chitosan isothiocyanate, followed by hybridization with promising fluorinated aromatic amines, producing three chitosan fluorinated-thiourea samples (CHTUD1–3).

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Cite This Study

Abusaif et al. (2026) studied this question.

synapsesocial.com/papers/69f2f19c1e5f7920c6387375 https://doi.org/10.1039/d6ma00145a

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Novel chitosan hybrid fluorinated thiourea derivatives as dual anti-microbial and anti-biofilm agents: tailoring molecular interactions, in silico toxicity, and docking simulation

Key Points

Implication

Abstract

Discussion

Cite This Study

Novel chitosan hybrid fluorinated thiourea derivatives as dual anti-microbial and anti-biofilm agents: tailoring molecular interactions, in silico toxicity, and docking simulation

Key Points

Implication

Abstract

Discussion

Cite This Study

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