Why the study?
Does regional fibre stress-fibre strain area accurately estimate regional blood flow and oxygen demand during asynchronous electrical activation in the canine heart?
Population
n=6 anaesthetized dogs with open chests
Comparison
Asynchronous electrical activation of the… vs Early versus late activated regions
Design
Preclinical
Authors
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Mechanical power from fibre stress-strain area may better estimate regional demand in dyssynchrony; leaves open translation beyond canine models.
Does regional fibre stress-fibre strain area accurately estimate regional blood flow and oxygen demand during asynchronous electrical activation in the canine heart?
Regional total mechanical power derived from the fibre stress-fibre strain area provides a better and more general estimate of regional oxygen demand than the regional pressure-sarcomere length area during asynchronous electrical activation.
Delhaas et al. (1994) studied this question.
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