Why the study?
Does gp91(phox) deficiency prevent Angiotensin II-induced vascular hypertrophy and oxidative stress in mice?
Does gp91(phox) deficiency prevent Angiotensin II-induced vascular hypertrophy and oxidative stress in mice?
gp91(phox) and NADPH oxidase-derived superoxide anion are essential for basal BP regulation and mediate pressure-independent vascular hypertrophic and oxidant stress responses to Angiotensin II.
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gp91phox inhibition may prevent pressure-independent vascular hypertrophy; hypothesis-generating and requires human validation before clinical consideration.
Wang et al. (2001) studied this question.
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