Why the study?
Does aspirin 300 mg/day affect platelet fibrinogen binding and degranulation in normal subjects?
Does aspirin 300 mg/day affect platelet fibrinogen binding and degranulation in normal subjects?
Aspirin does not inhibit platelet fibrinogen binding or degranulation in response to physiological agonists, which may explain its partial efficacy in preventing thrombotic events.
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Aspirin may confer only partial platelet inhibition; leaves open whether adjunctive targeting of fibrinogen binding improves outcomes.
Chronos et al. (1994) studied this question.