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December 1, 1992Arteriosclerosis and Thrombosis A Journal of Vascular BiologyOpen Access

Activation of platelets in blood perfusing angioplasty-damaged coronary arteries. Flow cytometric detection.

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Why the study?

Does percutaneous transluminal angioplasty (PTCA) induce platelet activation in blood perfusing damaged coronary arteries?

Population

Patients undergoing percutaneous transluminal angioplasty, control patients undergoing coronary angiography…

Comparison

Percutaneous transluminal angioplasty (PTCA) vs Coronary angiography without PTCA

Design

Cohort

Follow-up

30 minutes after PTCA

Authors

RSRüdiger E. ScharfHeidelberg University ATAaron TomerTel Aviv University UMUlla M. MarzecOregon National Primate Research Center

Discussion

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Implication

May support periprocedural antiplatelet caution in PTCA; leaves open whether activation predicts events or warrants targeted therapy.

Structured PICO

Does percutaneous transluminal angioplasty (PTCA) induce platelet activation in blood perfusing damaged coronary arteries?

P

Population

Patients undergoing percutaneous transluminal angioplasty (PTCA) (n=5), control patients undergoing coronary angiography without PTCA (n=3), and patients providing peripheral blood during coronary angiography (n=8).

I

Intervention

Percutaneous transluminal angioplasty (PTCA)

C

Comparator

Coronary angiography without PTCA

O

Outcome

Platelet activation measured by flow cytometry (expression of activation-specific membrane GP epitopes including PAC1, anti-LIBS1, 9F9, and P-selectin)surrogate

PTCA induces significant local platelet activation in the coronary circulation, which can be detected using flow cytometry.

Cite This Study

Scharf et al. (1992) studied this question.

synapsesocial.com/papers/69f3ee8cdc238f819779986d https://doi.org/10.1161/01.atv.12.12.1475

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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Independent modulation of von Willebrand factor and fibrinogen binding to the platelet membrane glycoprotein IIb/IIIa complex as demonstrated by monoclonal antibody.1985 · 98 citations
2Detection of activated platelets in whole blood using activation- dependent monoclonal antibodies and flow cytometry1987 · 760 citations
3Morphology after Transluminal Angioplasty in Human Beings1981 · 485 citations
4Effects of platelet-modifying drugs on arterial thromboembolism in baboons. Aspirin potentiates the antithrombotic actions of dipyridamole and sulfinpyrazone by mechanism(s) independent of platelet cyclooxygenase inhibition.1985 · 123 citations
5The Pathogenesis of Coronary Artery Disease and the Acute Coronary Syndromes1992 · 3,733 citations