Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

Xuewei Huang; Lizhi Hu; Zhuojun Long; Xinyao Wang; Junru Wu; Jingjing Cai

doi:10.31083/j.rcm2503093

March 6, 2024Reviews in Cardiovascular MedicineOpen Access

Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

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Why the study?

Hypertensive heart disease presents a substantial global health burden spanning from subtle cardiac functional alterations to overt heart failure.

Key Points

To review the pathophysiological mechanisms, modern diagnostic imaging modalities, and emerging therapeutic interventions across the continuum of hypertensive heart disease.
Synthesized molecular, cellular, and clinical literature regarding neurohormonal, inflammatory, and metabolic pathways driving cardiac alterations.
Assessed contemporary cardiac imaging technologies used for phenotypic characterization and disease severity stratification.
Evaluated current and emerging management options, including pharmacological therapies, lifestyle interventions, and device-based modalities.
Neurohormonal activation, chronic inflammation, and metabolic remodeling collectively promote progressive myocardial hypertrophy, fibrosis, and eventual heart failure.
Advanced cardiac imaging tools enable precise identification of subclinical structural and functional cardiac changes, enhancing early risk stratification.
Multimodal therapeutic strategies targeting blood pressure control through lifestyle modifications, multi-drug pharmacological regimens, and novel device interventions mitigate adverse cardiac remodeling.

Design

Comprehensive review

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Implication

May inform clinician reference on hypertensive heart disease; leaves open validation of emerging therapies in prospective trials.

Abstract

Hypertensive heart disease (HHD) presents a substantial global health burden, spanning a spectrum from subtle cardiac functional alterations to overt heart failure. In this comprehensive review, we delved into the intricate pathophysiological mechanisms governing the onset and progression of HHD. We emphasized the significant role of neurohormonal activation, inflammation, and metabolic remodeling in HHD pathogenesis, offering insights into promising therapeutic avenues. Additionally, this review provided an overview of contemporary imaging diagnostic tools for precise HHD severity assessment. We discussed in detail the current potential treatments for HHD, including pharmacologic, lifestyle, and intervention devices. This review aimed to underscore the global importance of HHD and foster a deeper understanding of its pathophysiology, ultimately contributing to improved public health outcomes.

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Cite This Study

Huang et al. (2024) studied this question.

synapsesocial.com/papers/69f3ee99dc238f81977998ab https://doi.org/10.31083/j.rcm2503093

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Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

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Key Points

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Implication

Abstract

Discussion

Cite This Study

Hypertensive Heart Disease: Mechanisms, Diagnosis and Treatment

Figures

Key Points

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Implication

Abstract

Discussion

Cite This Study

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