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October 25, 2025Diabetes & MetabolismOpen Access

Increased epicardial adipose tissue is part of the phenotype of LMNA-associated partial lipodystrophy and could contribute to increased cardiovascular risk

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Why the study?

Patients with LMNA-associated familial partial lipodystrophy develop early CAD, but epicardial adipose tissue remains poorly described as a potential cardiovascular risk marker.

Is epicardial adipose tissue volume increased in patients with LMNA-associated partial lipodystrophy compared to patients with type-2 diabetes?

Population

26 patients with FPLD2 and 44 patients with T2D

Comparison

Patients with FPLD2 vs patients with T2D

Design

Comparative cross-sectional study using cardiac CT scans

Authors

SLSophie LamothePAPatricia AncelIBI. Belalem

Discussion

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Overview

May link EAT excess to CAD in FPLD2; leaves open causality and need for prospective studies.

Structured PICO

Is epicardial adipose tissue volume increased in patients with LMNA-associated partial lipodystrophy compared to patients with type-2 diabetes?

P
Population
70 patients, comprising 26 with LMNA-associated familial partial lipodystrophy (FPLD2) (24 women, 65% with diabetes, median age 49 [32;57] years) and 44 with type-2 diabetes (T2D) (40 women, median age 49 [41;59] years).
I
Intervention
LMNA-associated familial partial lipodystrophy (FPLD2) (exposure)
C
Comparator
Type-2 diabetes (T2D)
O
Outcome
Epicardial adipose tissue (EAT) volume measured from cardiac CT-scans using a deep-learning algorithmsurrogate

Patients with LMNA-associated familial partial lipodystrophy have significantly increased epicardial adipose tissue compared to patients with type-2 diabetes, which may contribute to their increased cardiovascular risk.

Cite This Study

Lamothe et al. (2025) studied this question.

synapsesocial.com/papers/69f3ef04dc238f8197799a3fhttps://doi.org/10.1016/j.diabet.2025.101710
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