Why the study?
Pathophysiological mechanisms contributing to mitral annular calcification are not fully understood, and surgical risk is often high in symptomatic patients, creating a need to summarize the disease process and treatment options.
This review highlights the pathophysiology, risk factors, and emerging transcatheter treatment options for patients with severe mitral annular calcification.
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May inform high-risk MAC decisions; leaves open need for RCTs on TMVI outcomes.
Ureña et al. (2025) studied this question.
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