Population
Human platelets (in vitro model)
Design
Preclinical
Authors
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Highlights dependence on secondary agonists for thromboxane-mediated aggregation; leaves open applicability to human platelet function and antithrombotic targets.
This mechanistic study demonstrates that thromboxane A2-induced platelet aggregation requires secondary secretion of agonists to stimulate Gi-coupled receptors, rather than direct dual signaling through its own receptor subtypes.
Paul et al. (1999) studied this question.
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