January 30, 2001Proceedings of the National Academy of SciencesOpen Access

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

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Why the study?

Does ALT-711 improve arterial and ventricular properties in old, healthy, nondiabetic primates?

Structured PICO

Does ALT-711 improve arterial and ventricular properties in old, healthy, nondiabetic primates?

Population

Old, healthy, nondiabetic Macaca mulatta primates (age 21 +/- 3.6 years)

Intervention

3-phenacyl-4,5-dimethylthiazolium chloride (ALT-711) 1.0 mg/kg body weight intramuscular injections every other day for 11 injections

Comparator

Baseline measurements (before treatment)

Outcome

Arterial stiffness indices (aortic pulse wave velocity [PWV] and augmentation [AGI] of carotid arterial pressure waveform) and echocardiographic determinations of LV structure and functionsurrogate

The cross-link breaker ALT-711 improved arterial and ventricular function and optimized ventriculo-vascular coupling in healthy older primates.

Discussion

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Implication

Hypothesis-generating for ALT-711 in age-related stiffness; human trials needed before any clinical consideration.

Cite This Study

Vaitkevicius et al. (2001) studied this question.

synapsesocial.com/papers/69f41d2df3e494ed2b7d0445 https://doi.org/10.1073/pnas.98.3.1171

Topics

Echocardiography

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A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Structured PICO

Discussion

Implication

Cite This Study

Topics

A cross-link breaker has sustained effects on arterial and ventricular properties in older rhesus monkeys

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Topics

Also Consider