Reveals distinct immune landscapes in breast cancer brain metastases, suggesting novel biomarkers for treatment response.
tissue-resident-like memory T cells as major players of tumor immune control. 2) BCBM containing tertiary lymphoid structures. Surrogate signatures of these landscapes are prognostic in independent BCBM and primary breast cancer cohorts, are associated with fewer metastases, and predict immunotherapy response. Our work provides critical insights into anti-tumor immunity in BCBM and identifies novel biomarkers with translational relevance.
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Jassowicz et al. (2026) studied this question.
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