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May 1, 2026Cancer Cell4 citationsOpen Access

Dissecting the cellular architecture of breast cancer brain metastases reveals prognostically distinct immune landscapes

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LJLena JassowiczFFFangyoumin FengRWRolf Warta

Key Points

  • The aim is to explore the immune landscapes of breast cancer brain metastases (BCBM) and their prognostic significance.
  • Examined tissue-resident memory T cells in BCBM and associated immune structures.
  • Identified prognostic surrogate signatures within independent cohorts of BCBM and primary breast cancer.
  • Analyzed response rates to immunotherapy based on immune landscape characteristics.
  • Prognostic immune landscapes were identified in BCBM, indicating distinct immune responses.
  • Fewer metastases were associated with the presence of tertiary lymphoid structures.
  • Surrogate signatures predicted immunotherapy response in both BCBM and primary breast cancer cohorts.

Abstract

tissue-resident-like memory T cells as major players of tumor immune control. 2) BCBM containing tertiary lymphoid structures. Surrogate signatures of these landscapes are prognostic in independent BCBM and primary breast cancer cohorts, are associated with fewer metastases, and predict immunotherapy response. Our work provides critical insights into anti-tumor immunity in BCBM and identifies novel biomarkers with translational relevance.

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Cite This Study

Jassowicz et al. (2026) studied this question.

synapsesocial.com/papers/69f44223967e944ac5565dd3https://doi.org/10.1016/j.ccell.2026.03.016
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