What question did this study set out to answer?

To assess acetylcholinesterase activity in erythrocytes as a biomarker for brominated flame retardants-induced cellular dysfunction.

May 1, 2026Cellular Physiology and Biochemistry0 citationsOpen Access

Acetylcholinesterase Activity in Erythrocytes: a Functional Sensor of Environmental Toxicity from Brominated Flame Retardants

MJMonika JarosiewiczUniversity of Łódź BBBożena BukowskaUniversity of Łódź

Key Points

To assess acetylcholinesterase activity in erythrocytes as a biomarker for brominated flame retardants-induced cellular dysfunction.
Measured acetylcholinesterase activity spectrophotometrically using Ellman's method.
Exposed erythrocytes to tetrabromobisphenol A, tetrabromobisphenol S, and bromophenols.
Evaluated enzyme activity changes at specific concentrations of compounds.
TBBPA and TBBPS significantly increased AChE activity at specific concentrations.
Significant effects on AChE activity were observed with 2,4,6-TBP and pentabromophenol.
The sensitivity of erythrocyte AChE as a biosensor is limited; detectable changes align with other cellular alterations.

Abstract

BACKGROUND/AIMS: Brominated flame retardants (BFRs) are widely used synthetic compounds with increasing environmental persistence and toxicological concern. This study investigated acetylcholinesterase (AChE) activity in human erythrocytes as a potential biomarker of BFR-induced cellular dysfunction. METHODS: AChE activity was measured spectrophotometrically using Ellman's method after exposure to selected compounds including tetrabromobisphenol A (TBBPA), tetrabromobisphenol S (TBBPS), and bromophenols. RESULTS: TBBPA and TBBPS significantly altered AChE activity, with increased enzyme activity observed at specific concentrations. Among bromophenols, significant effects were detected for 2,4,6-TBP and pentabromophenol. CONCLUSION: The biological effects of BFRs depend on chemical structure and concentration. While erythrocyte AChE responds to exposure, it is not a highly sensitive biosensor, as detectable changes occur alongside other cellular alterations.

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Cite This Study

Jarosiewicz et al. (Mon,) studied this question.

synapsesocial.com/papers/69f44223967e944ac5565dee https://doi.org/https://doi.org/10.33594/000000863

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