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Discovery of a Structurally Distinct Acetylenase in the Biosynthesis of Mangotoxin. | Synapse

May 1, 20260 citations

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Discovery of a Structurally Distinct Acetylenase in the Biosynthesis of Mangotoxin.

EBEdward D. Badding EKElijah N. Kissman SVStefan V Velculescu

Key Points

To identify and characterize a novel acetylenase involved in the biosynthesis of mangotoxin.
Characterization of acetylenase structure and function
Comparison with known HDOs to explore mechanisms
Identified a unique acetylenase that operates through a new chemical mechanism
Expanded understanding of HDO chemistry beyond previously established pathways

Abstract

)-H bonds may utilize a mechanism distinct from other HDOs and expands the scope of known HDO chemistry.

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Cite This Study

Badding et al. (Tue,) studied this question.

synapsesocial.com/papers/69f4427a967e944ac5565ffd https://doi.org/https://doi.org/10.1021/jacs.5c21680

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