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May 1, 20263 citations

Regioselective Reductive Coupling of o-Haloaromatic Ketones with Terminal Alkynes via Photoredox/Cobalt Dual Catalysis.

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QGQian Gui-fenRZRuo-ping ZhengTMTingting Miao

Key Points

  • The research aims to develop a method for regioselective coupling of o-haloaromatic ketones with terminal alkynes.
  • Utilized photoredox and cobalt dual catalysis for reactions.
  • Employed bromoaromatic aldehydes and terminal alkynes as substrates.
  • Conducted reactions at room temperature using a tertiary amine as the reductant.
  • Achieved excellent regioselectivity in product formation.
  • Demonstrated broad substrate scope for the reaction conditions.
  • Reactions proceeded efficiently under mild conditions.

Abstract

-bromoaromatic aldehydes, with terminal alkynes to afford 2-substituted indenols. This protocol uses a tertiary amine as the terminal reductant, proceeds at room temperature, and features mild conditions, excellent regioselectivity, and broad substrate scope.

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Cite This Study

Gui-fen et al. (2026) studied this question.

synapsesocial.com/papers/69f4427a967e944ac5566122https://doi.org/10.1021/acs.orglett.6c01347
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