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May 1, 2026Open Access

Stability-Indicating Rp-HPLC Method Development and Validation for the Simultaneous Estimation of Luliconazole and Salicylic Acid in Its Topical Dosage Form

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Authors

RKRiya Dasadiya2 Manisha Kotadiya*1

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Overview

Randomized trial demonstrates a stability-indicating RP-HPLC method for estimating Luliconazole and Salicylic Acid in pharmaceutical dosage form, indicating its quality control suitability.

Key Points

  • To develop and validate a rapid, precise, and stability-indicating RP-HPLC method for Luliconazole and Salicylic Acid.
  • Developed RP-HPLC method using YMC Pack ODS-A column and Buffer: Methanol (30:70 % v/v) as mobile phase at 1.0 mL/min flow rate.
  • Assessed method linearity, accuracy, and sensitivity with LOD and LOQ calculations.
  • Conducted forced degradation studies to confirm stability-indicating capacity.
  • Method showed excellent linearity with R² values > 0.998 for both compounds in specified concentration ranges.
  • Recoveries were 98% for Luliconazole and 99.6% for Salicylic Acid, indicating high accuracy.
  • Stability-indicating studies revealed clear separation of degradation products under stress conditions.

Cite This Study

Riya Dasadiya2 Manisha Kotadiya*1 (2026) studied this question.

synapsesocial.com/papers/69f442d4967e944ac556652bhttps://doi.org/10.5281/zenodo.19876082
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