Key result
Higher Life's Essential 8 scores linked to lower hs-CRP levels in adolescents.
Why the study?
To investigate cardiovascular health and its association with low-grade inflammation in adolescents.
Is cardiovascular health associated with low-grade inflammation in adolescents?
Cohort (n=1,379)
Is cardiovascular health associated with low-grade inflammation in adolescents?
In Austrian adolescents, moderate cardiovascular health based on the Life's Essential 8 score is inversely associated with systemic inflammation as measured by hs-CRP.
AIM: This Prospective, Community-Based Cohort Study Investigated Cardiovascular Health and Its Association With Low-Grade Inflammation in Adolescents. METHODS: Data were collected by specially trained medical staff from 1379 Austrian adolescents aged 14-19 years from 3 February 2021 to 28 February 2023. These included a self-report, assisted questionnaire and structured interview. Cardiovascular health was assessed using the American Heart Association's Life's Essential 8 score and chronic low-grade inflammation was measured by high-sensitivity C-reactive protein levels. Associations were analysed using multivariable linear regression. RESULTS: The average Life's Essential 8 score suggested 75.0% adherence to ideal cardiovascular health recommendations and 68.2% of the cohort had moderate total cardiovascular health scores. High-sensitivity C-reactive protein levels indicated that 66.5% of the adolescents had a low risk of cardiovascular disease. These levels were associated with the total Life's Essential 8 scores (p < 0.001), as well as age (p < 0.001), female sex (p < 0.001), dietary habits (p = 0.029), active smoking (p < 0.001), higher body mass index z-scores (p < 0.001), and oral hormonal contraceptive use (p < 0.001). CONCLUSION: Overall, cardiovascular health was moderate and showed an inverse relationship with high-sensitivity C-reactive protein levels. Improved dietary habits, appropriate physical activity and not using tobacco may help to reduce systemic inflammation and cardiovascular risks.
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Mueller et al. (2026) conducted a cohort in Cardiovascular health (n=1,379). Cardiovascular health assessment (Life's Essential 8) was evaluated on Association between Life's Essential 8 score and high-sensitivity C-reactive protein levels (p=<0.001). Cardiovascular health, assessed by Life's Essential 8 scores, showed an inverse relationship with high-sensitivity C-reactive protein levels (p < 0.001) among Austrian adolescents.
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