Plasma Exosomal miR-106b-5p Is Associated With Osteoporosis by Targeting SMAD5, BMP2, and MAPK1 Genes.

BACKGROUND/AIM: This study aimed to explore the expression, function, and regulatory mechanism of exosomal miR-106b-5p in osteoporosis (OP), to identify a novel diagnostic biomarkers and therapeutic targets. MATERIALS AND METHODS: . healthy controls=139:139) to identify OP-associated miRNAs. Lentivirus-infected MC3T3-E1 and RAW264.7 cells were used to investigate the impact of upregulated miR-106b-5p on the proliferation, apoptosis, and differentiation of osteoblasts and osteoclasts, respectively. Target genes were predicted via bioinformatics. RESULTS: genes. CONCLUSION: to suppress bone formation and enhance resorption, representing a potential diagnostic biomarker and therapeutic target.