Shewanella oneidensis Metabolically Engineered with Prussian Blue for Synergistic Tumor Microenvironment Remodeling and Photodynamic Breast Tumor Elimination.

Key Points

• The research aims to enhance tumor elimination and remodel the tumor microenvironment using a hybridized microbial system.
• Developed a biohybrid system combining Shewanella oneidensis with Prussian Blue for enhanced functionality.
• Utilized photodynamic therapy principles for tumor treatment within the microenvironment.
• Achieved durable tumor eradication and significant remodeling of the tumor microenvironment.
• Demonstrated potential for developing safe and effective microbe-based cancer therapies.