Graphene quantum dot-coated mesoporous silica loaded with glucosamine sulfate as a potent antigen delivery system for immunoactivation.

Qiran Wang; Shuyao Yang; Yao Wang; Hangyu Li; Yuanzuo Li; Xihui Du; Qian Yang; Fengyuan Wang; Haibo Feng

doi:10.1038/s42003-026-10113-2

April 28, 2026

Graphene quantum dot-coated mesoporous silica loaded with glucosamine sulfate as a potent antigen delivery system for immunoactivation.

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Key Points

This research aims to evaluate the effectiveness of a novel antigen delivery system using graphene quantum dot-coated mesoporous silica.
In vivo experiments were conducted to test the effects of MSN-G-Q/OVA on immune organ indices.
Dendritic cell maturation and T lymphocyte proliferation were assessed in response to the antigen delivery system.
Cytokine levels, including IFN-γ, IL-4, and IL-1β, were measured to evaluate immunostimulatory effects.
MSN-G-Q/OVA significantly increased immune organ index and promoted dendritic cell maturation.
T lymphocyte proliferation was elevated, showing a positive immunological response.
Antigen-specific IgG antibodies and cytokines were significantly higher compared to control.

Implication

Shows that graphene quantum dot-coated silica enhances immune response, indicating strong potential for immunotherapy.

Abstract

expression. In vivo, MSN-G-Q/OVA increases immune organ index, facilitates dendritic cell (DC) maturation, promotes T lymphocyte proliferation and differentiation, elevates antigen-specific IgG antibodies and cytokines, including IFN-γ, IL-4, and IL-1β, and prolongs ovalbumin (OVA) residence in immune organs and lymph nodes. The results show that MSN-G-Q/OVA is a promising immunostimulatory antigen delivery system.

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Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/69f4435b967e944ac5566a3b https://doi.org/10.1038/s42003-026-10113-2

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Graphene quantum dot-coated mesoporous silica loaded with glucosamine sulfate as a potent antigen delivery system for immunoactivation.

Key Points

Implication

Abstract

Discussion

Cite This Study

Graphene quantum dot-coated mesoporous silica loaded with glucosamine sulfate as a potent antigen delivery system for immunoactivation.

Key Points

Implication

Abstract

Discussion

Cite This Study

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