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April 28, 2026MoleculesOpen Access

Acid Degradation, Structure Characterization of a Novel Polysaccharide from Leaves of Isatis indigotica Fort. with Immunomodulatory Activity

Yu Shen Xuefeng Wang H Zhang Yuliang Wang Zheng Wang Y Zhang Hongbo Zhao

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Key Points

This study aims to investigate the immunomodulatory properties and structural characterization of a novel polysaccharide from Isatis indigotica leaves.
Polysaccharide DFIP-A3-1 was isolated using ultrafiltration and chromatography techniques.
Structural analysis included HPGPC, GC-MS, FT-IR, SEM, AFM, and NMR.
Immunomodulatory effects were assessed through NO, IL-6, and TNF-α secretion in RAW 264.7 cells.
DFIP-A3-1 showed significant upregulation of NO, IL-6, and TNF-α secretion in RAW 264.7 cells.
Molecular pathway activation was confirmed through increased levels of p-IκBα, p-p65, and TLR4.
Co-treatment with TAK-242 suppressed the expression of pathway-related proteins.

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Implication

Reveals immunomodulatory effects of DFIP-A3-1 in vitro, suggesting therapeutic potential.

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Cite This Study

Shen et al. (2026) studied this question.

synapsesocial.com/papers/69f4435b967e944ac5566a51 https://doi.org/10.3390/molecules31091461

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