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December 1, 2026

Micafungin microevolution in Candida auris reveals resistance development without in vivo fitness compromise.

Flora Bohner Zóra Szilovics Éva Veres Csaba Papp Joshua D. Nosanchuk Attila Gácser

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Key Points

The aim is to investigate the microevolution of Candida auris regarding resistance to micafungin without loss of pathogenicity.
Investigated micafungin resistance in Candida auris through genetic and biochemical analyses.
Assessed pathogenicity in clinical isolates to evaluate fitness levels.
Candida auris demonstrated acquired resistance to micafungin without a reduction in pathogenicity.
Resistance development supports the ongoing spread in healthcare environments.

Implication

Investigates resistance development in Candida auris, suggesting persistence in clinical settings.

Abstract

can acquire echinocandin resistance without compromising pathogenicity, supporting its persistence and spread in clinical settings.

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Cite This Study

Bohner et al. (2026) studied this question.

synapsesocial.com/papers/69f44390967e944ac5566b50 https://doi.org/10.1080/21505594.2026.2664993

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1FKS1/2-variant independent mechanisms underlying the emergence of resistance in echinocandin-refractory Candida auris infectionsOriginal Research · 2026
2In vitro evolution of caspofungin resistance in Candidozyma auris via FKS1 hotspot I mutations results in moderate fitness trade-offs but no reduction in virulence2025 · 6 citations
3Evolutionary accumulation of <i>FKS</i> 1 mutations from clinical echinocandin-resistant <i>Candida auris</i>2024 · 29 citations
4Multidrug Resistance and Host Adaptation in Candida Auris: From Molecular Mechanisms to Emerging Therapeutic FrontiersNarrative Review · 2026
5Mutation, biofilm formation, and cell wall remodeling contribute to echinocandin resistance of <i>Candidozyma auris</i>Original Research · 2026 · 2 citations

Echinocandin persistence directly impacts the evolution of resistance and survival of the pathogenic fungus <i>Candida glabrata</i>2024
Echinocandin Resistance in Candida2015
Deciphering the multidrug resistance paradigm in <i>Candida auris</i>2026

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