Key result
Luteolin protects H9c2 cardiomyocytes from H2O2-induced apoptosis by modulating AMPK/mTOR signaling and inhibiting excessive mitophagy.
Should not alter clinical practice; leaves open PPARγ-PINK1 insights on cardiomyocyte mitophagy for translational studies.
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Yang et al. (2026) studied H2O2-induced mitophagy and apoptosis in cardiomyocytes. Luteolin vs. H2O2 was evaluated on Upregulation of proteins associated with the AMPK/mTOR signaling axis, mitophagy, and apoptosis. Luteolin protected H9c2 cardiomyocytes from H2O2-induced mitochondria-mediated apoptosis by modulating the AMPK/mTOR signaling pathway and inhibiting excessive mitophagy.
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