Should we follow the penicillin allergy label trail in approaching patients with a sulfonamide allergy label?

Proactive evaluation and de-labeling of sulfonamide allergy through direct oral challenge with trimethoprim-sulfamethoxazole could be considered in patients who are immunocompromised, patients with recurrent acute cystitis, and those with multiantibiotic allergy. Further research is needed to identify systematic hospital-wide interventions and to elucidate the benefit of such de-labeling on clinical outcomes.