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Synapse
May 1, 2026

Informatics Infrastructure for the Learning Health System.

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Authors

JTJessica D TenenbaumJCJames J. CiminoDDDavid A Dorr

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Overview

Review examines informatics in fostering knowledge generation and healthcare improvement in learning health systems.

Key Points

  • This review investigates the foundations and roles of informatics in the learning health system (LHS) framework.
  • Described the origins and foundations of the learning health system.
  • Examined the role of informatics and data science in the LHS cycle.
  • Discussed governance and culture change related to LHS implementation.
  • Identified how informatics serves as both infrastructure and a driving force in the LHS.
  • Highlighted the significance of data analysis in improving healthcare systems.
  • Addressed unresolved challenges and future directions for LHS evolution.

Cite This Study

Tenenbaum et al. (2026) studied this question.

synapsesocial.com/papers/69f443cb967e944ac5566eeahttps://doi.org/10.1146/annurev-biodatasci-092624-103225
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