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April 14, 2026

NDRG2 Drives DRP1 Phosphorylation to Promote the Progression of Pulmonary Hypertension.

Jiayong Luo Jinyu Chang Yi Liu Yusang Shao Yanyan Zhang Yingru Zheng Enfang Xiao Yanqing Xie Shuangshuang Tu Haoxuan Lu Wenming He

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Key Points

This research aims to investigate the impact of NDRG2 on pulmonary hypertension progression via its interaction with DRP1.
Investigated NDRG2 and DRP1 interaction using co-immunoprecipitation and immunofluorescence.
Conducted an in vivo rescue experiment with intratracheal AAV9-shNDRG2 delivery in SuHx rats.
NDRG2 knockdown improved hemodynamic indices and right ventricular hypertrophy in SuHx rats.
Knockdown reduced pulmonary vascular remodeling and enhanced exercise capacity in SuHx rats.

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Implication

Demonstrates NDRG2's role in promoting pulmonary hypertension, indicating potential therapeutic targets.

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Cite This Study

Luo et al. (2026) studied this question.

synapsesocial.com/papers/69f443e8967e944ac5566f75 https://doi.org/10.31083/fbl48054

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4Identification and functional analysis of NAD+ metabolism-related gene NT5E in pulmonary hypertensionOriginal Research · 2026
5Phosphorylation disrupts the interaction between the intrinsically disordered region of the oncogenic <scp>NDRG1</scp> and lipid vesiclesOriginal Research · 2026 · 1 citations

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