Macrophage Ubiquitin-Activating Enzyme 1 Promotes Sepsis-Associated Acute Kidney Injury by Relieving Nucleoporin 35-Mediated Suppression of Nuclear Factor-κB Signaling.

Siyi Lv; Changting Cui; Lu-Yuan Jin; Wenxi Jiang; H W Li

doi:10.1177/15230864261443780

April 28, 2026

Macrophage Ubiquitin-Activating Enzyme 1 Promotes Sepsis-Associated Acute Kidney Injury by Relieving Nucleoporin 35-Mediated Suppression of Nuclear Factor-κB Signaling.

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Key Points

To investigate the role of UBA1 in macrophage-induced kidney damage during sepsis-related acute kidney injury.
Examined the function of UBA1 in macrophages during sepsis-associated acute kidney injury.
Analyzed the effect of nucleoporin 35 on NF-κB signaling pathways.
Utilized various molecular techniques to elucidate mechanisms of renal injury.
UBA1 was found to enhance kidney injury by modulating NF-κB signaling.
Inhibition of nucleoporin 35 restored NF-κB signaling and ameliorated kidney damage in sepsis.
Findings indicate that targeting UBA1 may have therapeutic potential for SA-AKI.

Implication

Investigates UBA1's role in sepsis-associated acute kidney injury, suggesting a novel therapeutic target.

Abstract

AIMS: To determine the role of the ubiquitin-activating enzyme UBA1 in macrophage-mediated renal injury during sepsis-associated acute kidney injury (SA-AKI) and to elucidate the underlying molecular mechanism. METHODS AND INNOVATION AND CONCLUSIONS: 00, 000-000.

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Cite This Study

Lv et al. (2026) studied this question.

synapsesocial.com/papers/69f44420967e944ac5567227 https://doi.org/10.1177/15230864261443780

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Macrophage Ubiquitin-Activating Enzyme 1 Promotes Sepsis-Associated Acute Kidney Injury by Relieving Nucleoporin 35-Mediated Suppression of Nuclear Factor-κB Signaling.

Key Points

Implication

Abstract

Discussion

Cite This Study

Macrophage Ubiquitin-Activating Enzyme 1 Promotes Sepsis-Associated Acute Kidney Injury by Relieving Nucleoporin 35-Mediated Suppression of Nuclear Factor-κB Signaling.

Key Points

Implication

Abstract

Discussion

Cite This Study

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