Retrospective Analysis of Dronedarone Versus Amiodarone on Outcomes Following Radiofrequency Ablation for Atrial Fibrillation.

AIMS/BACKGROUND: Pharmacological therapy can enhance the therapeutic efficacy of radiofrequency ablation (RFA) for atrial fibrillation (AF) and reduce the risk of recurrence. Dronedarone and amiodarone are two commonly prescribed adjuvant medications. However, no consensus exists on which agent demonstrates superior efficacy. This study aimed to compare the effects of dronedarone and amiodarone on the prognosis of patients undergoing RFA for AF, thereby providing evidence-based guidance for clinical medication selection. METHODS: = 59) based on the postoperative medication received. Postoperatively, patients were treated with either dronedarone hydrochloride tablets or amiodarone hydrochloride tablets for 6 months. Long-term electrocardiographic monitoring (7-day duration via 5G network) was performed at 1, 3, 6, and 12 months postoperatively to assess recurrence of atrial arrhythmias. Follow-up assessments at the same intervals included thyroid, liver, and renal function, left atrial diameter (LAD), left ventricular ejection fraction (LVEF), and QT interval. CONCLUSION: Dronedarone and amiodarone are similarly effective in reducing the AF recurrence after RFA. However, dronedarone is associated with a lower risk of thyroid dysfunction and confers greater improvement in left atrial remodelling.