Xanthonolignoids from Hypericum curvisepalum with quorum sensing inhibitory activity against Chromobacterium violaceum

Key Points

• Investigate the quorum sensing inhibitory activity of undescribed xanthonolignoids from Hypericum curvisepalum against Chromobacterium violaceum.
• Identified and isolated three novel xanthonolignoids from Hypericum curvisepalum.
• Evaluated their effects on quorum sensing using Chromobacterium violaceum as the model organism.
• Conducted bioassays to measure antimicrobial activity and quorum sensing inhibition.
• All three xanthonolignoids demonstrated significant inhibition of quorum sensing in Chromobacterium violaceum.
• The inhibition led to reduced violacein production by 70% in high concentrations (p<0.01).
• Phytochemical analysis confirmed the structural novelty of these compounds.