Shows emodin reduces renal injury in diabetic rats, suggesting a protective role against nephrotoxicity.
BACKGROUND: Our previous study verified that lipid nephrotoxicity mediated by hypoxia-inducible factor-1 alpha (HIF-1α) activation aggravates diabetic tubular injury. This study investigated whether emodin, an inhibitor of HIF-1α, improves tubular injury by reducing lipid accumulation in diabetic tubules, and examined its underlying mechanism. METHODS: ). Moreover, emodin ameliorated lipid accumulation, cellular injury, and mitochondrial homeostasis imbalance in these cells. CONCLUSION: These data demonstrate that emodin prevents lipid accumulation and cellular injury in diabetic tubular epithelial cells, possibly by inhibiting HIF-1α activation and exerting a protective effect on mitochondria.
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Wang et al. (2026) studied this question.
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