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Retrospective multicenter study evaluates lymph node ratio's impact on prognosis in obstructive colorectal cancer patients, suggesting its use as a biomarker.
BACKGROUND/AIM: This study evaluated the association between lymph node ratio (LNR) and long-term prognosis in pathological node-positive patients with obstructive colorectal cancer (CRC) who underwent colonic stent insertion as a bridge to surgery. PATIENTS AND METHODS: his retrospective multicenter study included 75 node-positive patients with obstructive CRC treated with a colonic stent. Receiver operating characteristic analysis for 5-year relapse-free survival identified an optimal LNR cut-off of 0.125. Patients were thus classified into high-LNR (LNR-H, n=40) and low-LNR (LNR-L, n=35) groups. Clinicopathological factors, surgical outcomes, and survival were assessed. CONCLUSION: LNR appears to represent a practical biomarker, with an elevated LNR independently predicting long-term outcomes among patients with node-positive obstructive CRC undergoing stent placement before surgery.
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Shiraishi et al. (2026) studied this question.
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