Answers are grounded in this paper and cite their sources.
Retrospective analysis evaluates preoperative cachexia index's impact on overall survival in remnant gastric cancer, suggesting a new prognostic biomarker.
BACKGROUND/AIM: Remnant gastric cancer (RGC) remains a clinically challenging condition, and prognostic biomarkers reflecting host-related vulnerability are needed. The cachexia index (CXI), incorporating skeletal muscle mass, serum albumin, and the neutrophil-to-lymphocyte ratio, has been reported as a prognostic indicator in several malignancies. However, its clinical significance in RGC remains unclear. This study aimed to evaluate the prognostic value of preoperative CXI in patients undergoing curative resection for RGC. PATIENTS AND METHODS: We retrospectively analyzed 51 patients who underwent curative resection for RGC between January 2004 and December 2020. Sex-specific CXI cutoff values were determined using receiver operating characteristic curve analysis based on 5-year overall survival (OS). OS and disease-specific survival (DSS) were assessed using the Kaplan-Meier method and Cox proportional hazards models. CXI was not significantly associated with DSS. Non-cancer-related deaths occurred more frequently in the low-CXI group. CONCLUSION: Low preoperative CXI is an independent predictor of poor OS in patients with RGC and may reflect host-related vulnerability rather than tumor aggressiveness. CXI could serve as a useful biomarker for perioperative risk stratification in RGC.
No takes yet. Share an insight, caveat, or question.
Matsunaga et al. (2026) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: