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Synapse
May 1, 20261 citations

Multi-Target Neuroprotective Compound Exhibits EAAT2-Modulating and Alzheimer's Pathology-Attenuating Effects in In Vitro and In Vivo Models.

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AHAhmet HacımüftüoğluNSNurullah SaraçoğluSSSana Saffour

Key Points

  • The aim is to investigate a multi-target neuroprotective compound's effects on excitotoxicity and Alzheimer's pathology.
  • Utilized primary hippocampal neurons to assess neuroprotective effects against glutamate-induced excitotoxicity.
  • Employed astrocyte-based models to evaluate modulation of glutamatergic homeostasis and redox balance.
  • The compound showed significant neuroprotection against glutamate-induced excitotoxicity in primary neurons.
  • Modulated glutamatergic homeostasis and redox balance in astrocytes, supporting its potential as a candidate for early-stage Alzheimer's treatment.

Abstract

exerts neuroprotective effects against glutamate-induced excitotoxicity in primary hippocampal neurons while additionally modulating glutamatergic homeostasis and redox balance through functional mechanisms in astrocyte-based models, supporting its relevance as a multitarget preclinical candidate for early stage AD mechanisms.

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Cite This Study

Hacımüftüoğlu et al. (2026) studied this question.

synapsesocial.com/papers/69f44464967e944ac55675ffhttps://doi.org/10.1021/acschemneuro.5c00873
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Novel Insights into the Pleiotropic Neuroprotective Action of Synthetic Halogen Free Thyronamine-like Analogues2026
  2. 2In Silico Design of Multi-Target Compound Combinations against Alzheimer's Disease2025
  3. 3Repurposed β-lactam compounds as EAAT2 allosteric enhancers: An integrated virtual screening, docking, MD simulation, and ADMET study2026
  4. 4Amyloid β, Glutamate, Excitotoxicity in Alzheimer's Disease: Are We on the Right Track?2013 · 190 citations
  5. 5Potential Therapeutic Targets to Modulate the Endocannabinoid System in Alzheimer’s Disease2024 · 11 citations