Case report identifies diagnostic challenges of hypercalcaemia in granulomatous lung disease, emphasizing TB.
Granulomatous lung disease encompasses a broad range of differentials, including infection, inflammation and malignancy. The most frequent infective cause is tuberculosis (TB), which commonly presents with cough, fever, weight loss or night sweats [1]. However, it is possible for TB to manifest subclinically [2] without symptomatology in the presence of granulomatous changes, which can pose a diagnostic dilemma. There may be clues that overlap with other differentials, such as hypercalcaemia associated with sarcoidosis and malignancy. Here, we present the case of a patient posthumously diagnosed with TB, who presented with isolated hypercalcaemia and granulomatous lung disease without respiratory symptoms.
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Ganeshanathan V*, Epstein J, Koshy K, Thien F (2026) studied this question.
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