Demonstrates effective asymmetric N-H insertion in pyrazoles, suggesting new synthesis strategies for nitrogen compounds.
); the combination of Ir and squaramide catalysts mediates asymmetric protonation with excellent enantiocontrol. These findings establish a strategy for the asymmetric N-H insertion of pyrazoles, providing access to chiral nitrogen heterocycles previously inaccessible by asymmetric catalysis. This concept extends to indazole functionalization and enables the first disclosed asymmetric synthesis of a PARP7 inhibitor.
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Ruud et al. (2026) studied this question.
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