, and achieve 49.96% photothermal conversion efficiency. Theoretical calculations atomistically elucidate the mechanisms underlying the superior photothermal conversion and excellent photostability of PCB. The combined photodynamic and photothermal effects lead to promoted lymphocyte infiltration and aggravate intratumoral hypoxia and overcome cellular thermotolerance mechanisms, which successfully results in a pronounced 99.34% tumor growth inhibition without discernible histopathological damage to major organs or changes in body weight. These findings establish PCB NPs as a promising platform for next-generation precision cancer phototherapy, integrating rapid tumor targeting, deep-tissue imaging, hypoxia-resilient ROS generation, and potent photodynamic-photothermal effects within a single nanoprobe.
Zhao et al. (Wed,) studied this question.