Why the study?
Aortic stenosis with discordant markers of severity, characterized by aortic valve area in the severe range but low mean gradient, remains an unresolved clinical conundrum.
Does aortic valve calcification quantification by MDCT identify severe calcified aortic valve disease in patients with aortic stenosis and discordant severity grading?
Population
646 patients with normal left ventricular ejection fraction aortic stenosis
Comparison
Concordant vs discordant aortic stenosis severity grading by AVAi and MG
Design
Cross-sectional study
Authors
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Quantification of aortic valve calcification by MDCT is highly accurate for diagnosing severe aortic stenosis and reveals that at least half of patients with discordant low-gradient AS actually have severe calcified disease.
Does aortic valve calcification quantification by MDCT identify severe calcified aortic valve disease in patients with aortic stenosis and discordant severity grading?
Quantification of aortic valve calcification by MDCT is highly accurate for diagnosing severe aortic stenosis and reveals that at least half of patients with discordant low-gradient AS actually have severe calcified disease.
Clavel et al. (2013) studied this question.
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