April 1, 1993The Journal of Clinical Endocrinology & Metabolism
Assay of brain natriuretic peptide (BNP) in human plasma: evidence for high molecular weight BNP as a major plasma component in heart failure.
Why the study?
What are the plasma levels and molecular forms of brain natriuretic peptide (BNP) in normal subjects and patients with heart failure or myocardial infarction?
Population
Normal subjects, patients with congestive heart failure, recent myocardial infarction, chronic renal…
Design
Cross-sectional
Authors
Discussion
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Implication
Elevated BNP with high-MW forms in HF and MI is hypothesis-generating; leaves open diagnostic or prognostic utility pending prospective validation.
Structured PICO
What are the plasma levels and molecular forms of brain natriuretic peptide (BNP) in normal subjects and patients with heart failure or myocardial infarction?
P
Population
Normal subjects (n=48), patients with congestive heart failure (n=35), recent myocardial infarction (n=7), chronic renal failure, and normal subjects receiving BNP infusion (n=3).
I
Intervention
Measurement of plasma brain natriuretic peptide (BNP) using a newly developed radioimmunoassay (RIA).
O
Outcome
Plasma levels of immunoreactive BNP (IR-BNP) and its molecular weight forms.surrogate
This study demonstrates that BNP is markedly elevated in heart failure and myocardial infarction, with high molecular weight precursor forms constituting a major component of circulating BNP in these conditions.
Cite This Study
Yandle et al. (1993) studied this question.