Why the study?
The prognostic value of cardiac damage staging classifications across the haemodynamic spectrum of severe aortic stenosis remained unknown.
Does advanced cardiac damage staging predict five-year mortality in patients with severe aortic stenosis undergoing TAVI?
Does advanced cardiac damage staging predict five-year mortality in patients with severe aortic stenosis undergoing TAVI?
Cardiac damage staging classifications effectively stratify long-term mortality risk after TAVI across all hemodynamic subtypes of severe aortic stenosis.
May aid post-TAVI risk stratification across AS subtypes; hypothesis-generating, requires prospective validation before practice change.
BACKGROUND: The prognostic value of cardiac damage staging classifications across the haemodynamic spectrum of severe aortic stenosis (AS) remains unknown. AIMS: We aimed to investigate the prognostic impact of cardiac damage staging classifications in patients with high-gradient AS (HG-AS) and low-gradient AS (LG-AS) undergoing transcatheter aortic valve implantation (TAVI). METHODS: In a prospective TAVI registry, five-year mortality was evaluated for early stages of cardiac damage (stage 0, 1, or 2) and advanced stages of cardiac damage (stage 3 or 4) in patients with HG-AS, classical low-flow (LF) LG-AS, LF LG-AS with preserved ejection fraction (pEF), and normal-flow (NF) LG-AS. RESULTS: 1.52, 95% CI: 1.04-2.32 for NF LG-AS). CONCLUSIONS: Cardiac damage staging classifications stratified mortality after TAVI irrespective of AS subtype.
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Nakase et al. (2023) studied this question.
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