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May 20, 2021European Heart Journal - Cardiovascular ImagingOpen Access

Validation of aortic valve calcium quantification thresholds measured by computed tomography in Asian patients with calcific aortic stenosis

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Why the study?

Sex-specific aortic valve calcification thresholds had been proposed and validated in Caucasians, but their accuracy in Asians required validation.

Does AVC-density improve diagnostic accuracy for severe aortic stenosis in Asian patients compared to absolute AVC thresholds?

Population

1263 patients with calcific AS from seven international centres

Comparison

Asian vs Caucasian patients

Design

Multicentre observational validation study

Authors

EGEzéquiel GuzzettiJOJin Kyung OhMSMylène Shen

Discussion

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Overview

AVC-density may improve severe AS diagnosis in Asians; hypothesis-generating and should not yet change practice.

Structured PICO

Does AVC-density improve diagnostic accuracy for severe aortic stenosis in Asian patients compared to absolute AVC thresholds?

P
Population
1263 patients with calcific aortic stenosis (AS) from seven international centres, including 728 (57%) Asians and 573 (45%) women. Excluded: ≥moderate aortic/mitral regurgitation and bicuspid valve.
I
Intervention
Aortic valve calcification (AVC) and AVC-density quantification by computed tomography
C
Comparator
Caucasian patients and guideline-recommended absolute AVC thresholds
O
Outcome
Accuracy (% correctly classified) of sex-specific AVC and AVC-density thresholds for identifying severe ASsurrogate

While absolute AVC thresholds for severe AS are similar between Asians and Caucasians, AVC-density provides higher diagnostic accuracy in Asian patients, particularly women.

Cite This Study

Guzzetti et al. (2021) studied this question.

synapsesocial.com/papers/69f53edfe0fbb6efbd20381chttps://doi.org/10.1093/ehjci/jeab116
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