Why the study?
Do absolute changes in cardiac troponin concentrations have higher diagnostic accuracy than relative changes for diagnosing acute myocardial infarction in patients presenting to the emergency department?
Population
836 patients presenting to the emergency department with symptoms suggestive of acute myocardial infarction
Comparison
Absolute changes in high-sensitive cardiac… vs Relative changes in high-sensitive cardiac…
Design
Cohort, Blood samples collected in a blinded fashion; final diagnosis…
Follow-up
2 hours
Authors
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Absolute 2-h cTn changes may aid AMI diagnosis over relative changes; leaves open whether this improves outcomes or warrants practice change.
Do absolute changes in cardiac troponin concentrations have higher diagnostic accuracy than relative changes for diagnosing acute myocardial infarction in patients presenting to the emergency department?
Absolute changes in cardiac troponin levels at 2 hours provide significantly higher diagnostic accuracy for acute myocardial infarction than relative changes.
Reichlin et al. (2011) studied this question.
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