Potassium suppresses allosteric activation of ZAP-70-dependent T Cell Receptor signaling

Key Points

• This research investigates how potassium influences the activation of ZAP-70 in T cell receptor signaling.
• Analyzed T cell receptor signaling dynamics using potassium variations.
• Examined ligand discrimination in T cells exposed to varying potassium levels.
• Potassium significantly inhibited allosteric activation of ZAP-70-dependent signaling pathways.
• Demonstrated that increased potassium levels lead to reduced T cell response amplitude.