PulseExploreJournal ClubDebatesTrendingResearchersJournals
Instagram
HomeExploreJournal ClubTrending
Synapse
⌘+K
Synapse
May 2, 2026Molecular Medicine Reports2 citationsOpen Access

Mechanotransducer Piezo1 drives ventilator‑induced lung injury in lung epithelial cells via the calcineurin/NFATc3 pathway

MLMin LiSZShu-Li ZhangFYFeng Yuan

Key Points

  • The study aims to investigate how Piezo1 contributes to lung injury through specific signaling pathways.
  • Investigated the role of Piezo1 in lung epithelial cells regarding mechanotransduction.
  • Analyzed calcineurin/NFATc3 signaling pathways involved in ventilator-induced lung injury (VILI).
  • Evaluated pulmonary inflammation and barrier function.
  • Activated Piezo1 was linked to increased pulmonary inflammation and barrier dysfunction.
  • Calcineurin/NFATc3 signaling was confirmed to mediate these effects as potential therapeutic targets.

Abstract

/calcineurin/NFATc3 signalling axis that drives pulmonary epithelial inflammation and barrier dysfunction in VILI, suggesting that Piezo1 and its downstream signalling molecules are potential therapeutic targets.

Ask AI
Helpful
Bookmark
Share
View Full Paper

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/69f593f271405d493affec46https://doi.org/10.3892/mmr.2026.13893
Ask AI
Helpful
Bookmark
Share
View Full Paper