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April 28, 2026Archives of ToxicologyOpen Access

The role of cytotoxicity in the process of carcinogenesis

Michael Schwarz Bernd Epe Laura E. Wohak Carola Voss Andrea Hartwig

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Key Points

The aim is to investigate how cytotoxicity influences carcinogenesis and tumor promotion.
Analysis of long-term animal cancer studies focusing on high cytotoxic dose levels.
Examination of the role of reactive oxygen species in DNA damage.
Discussion of the signaling mechanisms related to sterile inflammation.
Findings suggest that cytotoxic doses may promote tumor growth through selective stimulation of dormant tumor precursors.
This growth stimulation is mediated by damage-associated molecular patterns, indicating a new mechanism of tumorigenesis.
Implications for risk assessment of non-genotoxic agents are highlighted.

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Implication

Discussion on cytotoxicity and its implications for cancer promotion in existing tumor precursors.

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Cite This Study

Schwarz et al. (2026) studied this question.

synapsesocial.com/papers/69f593f271405d493affec8f https://doi.org/10.1007/s00204-026-04408-w

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