STING agonists reduce genital chlamydial infection and attenuate inflammation and pathology.

Key Points

• This research aims to explore the effectiveness of STING agonists in reducing chlamydial infection and associated inflammation.
• Investigated the effects of STING agonists in a controlled mouse model.
• Observed both local and systemic tolerance to STING agonists in the subjects.
• STING agonists significantly reduced genital chlamydial infection.
• Treatment led to decreased inflammation and pathological consequences associated with infection.